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Both complete loss-of-function and reduced function variants may result in a reduction of treatment efficacy, with atypical metabolite formation (e.g., switching from coumarin 7-hydroxylation to 3-hydroxylation) (Hadidi et al., 1997

To confirm that YAP regulates GS expression in mouse brain astrocytes, we crossed YAP flox/flox mice 25 and Aldh1l1-CreER T2 mice 26 to generate Aldh1l1-CreER T2 :YAP flox/flox mice, and selectively knocked out YAP in astrocytes upon tamoxifen administration (Fig

the liposomes may also comprise cholesterol or other sterols such as plant sterols where the weight ratio of the phospholipid to sterol is between about 5:1 and 20:1, and more preferably about 10:1

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After Se is absorbed into the body, it is regulated by key hepatic enzymes and other regulatory factors, and then synthesized into selenoproteins (Gammelgaard et al., 2012)